Located in Vatican City, the Hotel Santa Maura 2 is a perfect base while in Rome. Church of Saint Athanasius on Via Tiburtina, Papal Basilica of Saint Lawrence Outside the Walls and Church of Saint Anthony of Padua on Via Tuscolana are within a 20 minute drive from the hotel.

Local attractions near the Hotel Santa Maura 2 include the Policlinico Umberto I and Basilica of the Holy Cross in Jerusalem. The centre of Rome is 20 minutes away by car. Rome Ciampino Airport (CIA) is a 20 minute drive from the hotel. Santa Maria Ausiliatrice, Circolo del Golf di Roma and Policlinico Tor Vergata are a short drive from the hotel.